2 edition of role of acetone in the anticonvulsant actions of the ketogenic diet in rats. found in the catalog.
role of acetone in the anticonvulsant actions of the ketogenic diet in rats.
Kirk Jon Nylen
Written in English
The ketogenic diet (KD) is used to treat drug-resistant seizures. The goal of the present studies was to understand the KD"s mechanism of action. Experiments 1 and 2 compared the ability of 2 KD"s to elevate seizure threshold in adult rats and rat pups. It was concluded that the KD does not have anticonvulsant actions in rats. We then hypothesized that acetone is the anticonvulsant mechanism of the KD, and that rats on the KD do not develop therapeutic levels of acetone. Experiment 3 determined that seizures themselves decrease in vivo acetone levels, therefore, measuring acetone post-seizure should be performed cautiously. Experiment 4 demonstrated that acetone is not elevated in KD-fed rats, but it is elevated in KD-fed rats when acetone"s metabolism was inhibited. Finally, it was determined that acetone suppressed focal cortical and generalized convulsive seizures in the kindling model, but not amygdala focal seizures.
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how the ketogenic diet works in both human4, 9, 10, 13and animal15, 17, 18studies. Several authors believe that the anticonvulsant effects of the ketogenic diet are related to the ketosis and production of AcAc and/or BHB.3, 4, 9, 10, 13, 19The protection against seizures by elevated blood levels of BHB and AcAc in animals also has been studied. Perhaps the most common medical test obtained in patients with epilepsy is the EEG (electroencephalogram). This test is done to look for abnormal electrical activity associated with epilepsy and it can also indicate how effective (or not) treatment is.
Scientists have identified specific gut bacteria that play an essential role in the anti-seizure effects of the ketogenic diet. The study is the first to establish a causal link between seizure. Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet (KD) remain unclear, a long-standing question has been whether ketone bodies (i.e., β-hydroxybutyrate, acetoacetate and acetone), either alone or in combination, contribute by:
Methods: Male Sprague Dawley rats fed either ketogenic or regular diets were administered ethanol or water orally, twice daily for 6 days while the diet conditions were maintained. Abstinence symptoms were rated 6, 24, 48, and 72 hours after the last alcohol administration. The Cantin Ketogenic Diet. K likes. This book is about how I linked Type I diabetes & Cancer with Epilepsy, and how I optimized the traditional ketogenic diet to get rid of my cancer and to be Followers: K.
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Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet, exhibits anticonvulsant properties that may contribute to the seizure protection conferred by the diet. The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role.
Acetone and its. Recent interest in the anticonvulsant effects of acetone has stemmed from studies related to the ketogenic diet (KD). The KD, a high-fat diet used to treat drug-resistant seizures, raises blood. One well-known connection in the medical community between a ketogenic diet and health benefits is the ability to calm neurological conditions like epilepsy.
In a study with rats, researchers found acetone suppressed seizures in four types of experimental animal models. BACKGROUND: Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet, exhibits anticonvulsant properties that may contribute to the seizure protection conferred by the diet.
The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a by: The present study was designed to evaluate the anticonvulsant effects of a high-fat ketogenic diet (KD) in rats.
Animals were maintained on one of four experimental diets: (1) calorie-restricted. Introduction. The ketogenic diet initially was developed in the s in response to the observation that fasting had antiseizure properties .During fasting, the body metabolizes fat stores via lipolysis and then the fatty acids undergo beta-oxidation into acetoacetate, β-hydroxybutyrate, and acetone—ketone bodies the cell can then use as precursors to generate adenosine triphosphate (ATP).Cited by: tection conferred by the diet.
The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role. Methods: Acetone and its major metabolites—acetol, 1,2-propanediol, methylglyoxal, and pyruvic acid—were assessed for anticonvulsant activity in two mouse seizure models.
Vari. Szot P. () The Role of Norepinephrine in the Anticonvulsant Mechanism of Action of the Ketogenic Diet. In: Stafstrom C.E., Rho J.M. (eds) Epilepsy and the Ketogenic Diet. Nutrition and by: 3. The ketogenic diet enhances overall cellular bioenergetics and reduces oxidative stress.
• Glycolytic diversion and/or restriction may play an important role in the clinical activity of the ketogenic diet. • Modulation of tricarboxylic acid cycle flux may also underlie ketogenic diet by: Free Online Library: Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet.(Automation and Analytical Techniques) by "Clinical Chemistry"; Acetone Measurement Physiological aspects Animal behavior Animal experimentation Blood glucose Blood sugar Cellulose Diabetes Diabetes mellitus Disaccharides Epilepsy Essential fatty acids Low carbohydrate.
Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet (KD) remain unclear, a long-standing question has been whether ketone bodies (i.e., b-hydroxybutyrate, acetoacetate and acetone), either alone or in combination, contribute mechanistically.
The traditional belief has beenFile Size: KB. Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. Sergei S. Likhodii PhD 1,*, Irina Serbanescu BA 2,3, Miguel A. Cortez MD 2,3, Patricia Murphy PhD 1, O. Carter Snead III MD, 1,2,3 and; W.
McIntyre Burnham PhD 1; Article first published online: 26 JUN The Atkins diet and ketogenic diet are often used synonymously; however, they are different. While both diets lower carbohydrate consumption, the Atkins diet allows for a period in which both protein and carbohydrate intakes are increased (while fat intake is lowered) beyond what would classify as ketogenic.
The ketogenic diet is commonly used in conjunction with one of more anticonvulsant medication, and more is being learned about the risks and benefits of these combinations.
To begin with, the ketogenic diet does not seem to change the blood (plasma) levels of common anticonvulsant medications in any significant way. Ketone bodies (such as beta-hydroxybutyrate, acetoacetate and acetone) are a hallmark feature of the ketogenic diet.
• Ketone bodies have been shown to counter neuronal hyperexcitability in vitro and to exert anti-seizure effects in vivo. Beyond an energy substrate role, ketone bodies have epigenetic, anti-oxidant, mitochondrial and anti-inflammatory by: Ketonemia and Seizures: Metabolic and Anticonvulsant Effects of Two Ketogenic Diets in Childhood Epilepsy Peter R Huttenlocher 1 Pediatric Research vol pages – ( Cited by: The ketogenic diet (KD) is a high-fat diet that has been used to treat various types of medically refractory epilepsy.1 The KD might also slow the progression of the disorder.2,3 During treat-ment, ketone bodies are thought to become a signifi-cant energy substrate for the brain, but how this met-abolic adaptation confers the anticonvulsant.
Susan Masino, PhD Vernon Roosa Professor of Applied Science Trinity College Susan Masino, Ph.D. Susan Masino is the Vernon Roosa Professor of Applied Sci.
routes: exogenous administration of ketone bodies, implementation of the ketogenic diet in animal models, or in vitro studies of ketone bodies in brain slices. An underlying theme of these studies is to understand the potential anticonvulsant role of ketosis, the clinical hallmark of successful implementation of the KD in a patient.
This review. The first to publish results showing the effectiveness of the ketogenic diet in epilepsy was Dr. Peterman, a paediatrician from the Mayo clinic in At the time the use of the KD was hyped due to limited alternatives, falling out of favour in the late s due to its unpalatability and the emergence of AEDs like phenytoin [ 26, 27, 28 ].Cited by:.
A ketogenic diet is an important therapy used in the control of drug-refractory seizures. Many studies have shown that children and adolescents following ketogenic diets exhibit an over 50% reduction in seizure frequency, which is considered to be clinically relevant.
The anticonvulsant mechanism of the KD is unknown. To determine if the noradrenergic system has a role in mediating the anticonvulsant action of the KD, dopamine β-hydroxylase knockout (Dbh -/-) mice that lack norepinephrine (NE) and Dbh +/- littermates that have normal NE content were fed either a standard rodent chow or the KD Cited by: 27 Ketogenic Diet and Epilepsy: The Role of Adenosine often in children, the KD and related dietary formulations are also effective in adolescents and adults (Payne et al.
). A recent case report describes how initiation with a KD, and maintenance with a modi ed Atkins diet, was able to.